2025
Mark Germanos, Belinda Yau, Matthew Taper, Cara Yeoman, Amy Wilson, Yousun An, Jerome Cattin-Ortolá, Drew Masler, Jason Tong, Sheyda Naghiloo, Elise J Needham, A Gabrielle van der Kraan, Kitty Sun, Thomas Loudovaris, Alexis Diaz-Vegas, Mark Larance, Helen Thomas, Helen von Blume, Peter Thorn, Michael Ailion, Cedric Asensio, Melkam Alamerew Kebede. Cab45G trafficking through the insulin secretory pathway is altered in human type 2 diabetes. iScience,Volume 28, Issue 2, 2025. https://doi.org/10.1016/j.isci.2024.111719.
Yau B, An Y, Germanos M, Schwarzkopf P, van der Kraan AG, Larance M, Webster H, Burns C, Asensio CS, Kebede MA. VPS41 deletion triggers progressive loss of insulin stores and downregulation of beta-cell identity. Am J Physiol Endocrinol Metab. 2024 Dec 23. Epub ahead of print. PMID: 39716868. doi: 10.1152/ajpendo.00389.2024.
Hao H, Yuan Y, Ito A, Eberand BM, Tjondro H, Cielesh M, Norris N, Moreno CL, Maxwell JWC, Neely GG, Payne RJ, Kebede MA, Urbauer RJB, Passam FH, Larance M, Haltiwanger RS. FUT10 and FUT11 are protein O-fucosyltransferases that modify protein EMI domains. Nat Chem Biol. 2025 Jan 7. doi: 10.1038/s41589-024-01815-x. Epub ahead of print. PMID: 39775168.
2024
Norris N, Yau B, Famularo C, Webster H, Loudovaris T, Thomas HE, Larance M, Senior AM, Kebede MA. Optimised proteomic analysis of insulin granules from MIN6 cells identifies Scamp3, a novel regulator of insulin secretion and content. Diabetes. 2024 Sep 25:db240355. doi: 10.2337/db24-0355. Epub ahead of print. PMID: 39320956.
Diaz-Vegas A, Cooke KC, Cutler HB, Yau B, Masson SWC, Harney D, Fuller OK, Potter M, Madsen S, Craw NR, Zhang Y, Moreno CL, Kebede MA, Neely GG, Stöckli J, Burchfield JG, James DE. Deletion of miPEP in adipocytes protects against obesity and insulin resistance by boosting muscle metabolism. Mol Metab. 2024 Aug;86:101983. doi: 10.1016/j.molmet.2024.101983. Epub 2024 Jul 1. PMID: 38960128; PMCID: PMC11292358.
Thillainadesan S, Lambert A, Cooke KC, Stöckli J, Yau B, Masson SWC, Howell A, Potter M, Fuller OK, Jiang YL, Kebede MA, Morahan G, James DE, Madsen S, Hocking SL. The metabolic consequences of ‘yo-yo’ dieting are markedly influenced by genetic diversity. Int J Obes (Lond). 2024 Aug;48(8):1170-1179. doi: 10.1038/s41366-024-01542-2. Epub 2024 Jul 3. PMID: 38961153; PMCID: PMC11281900.
Yau B, Madsen S, Nelson ME, Cooke KC, Fritzen AM, Thorius IH, Stöckli J, James DE, Kebede MA. Genetics and diet shape the relationship between islet function and whole-body metabolism. Am J Physiol Endocrinol Metab. 2024 May 1;326(5):E663-E672.
2023
Melkam A. Kebede, Belinda Yau, Jacqueline Stöckli, Robert C. Piper, David E. James, Regulated Versus Constitutive Secretion – A Major Form of Intercellular Communication, Editor(s): Ralph A. Bradshaw, Gerald W. Hart, Philip D. Stahl, Encyclopedia of Cell Biology (Second Edition), Academic Press, 2023, Pages 455-464, ISBN 9780128216248, https://doi.org/10.1016/B978-0-12-821618-7.00025-0.
Keller MP, Hudkins KL, Shalev A, Bhatnagar S, Kebede MA, Merrins MJ, Davis DB, Alpers CE, Kimple ME, Attie AD. What the BTBR/J mouse has taught us about diabetes and diabetic complications. iScience. 2023 Jun 7;26(7):107036. doi: 10.1016/j.isci.2023.107036. PMID: 37360692; PMCID: PMC10285641.
Thai LM, O’Reilly L, Reibe-Pal S, Sue N, Holliday H, Small L, Schmitz-Peiffer C, Dhenni R, Wang-Wei Tsai V, Norris N, Yau B, Zhang X, Lee K, Yan C, Shi YC, Kebede MA, Brink R, Cooney GJ, Irvine KM, Breit SN, Phan TG, Swarbrick A, Biden TJ. β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling. iScience. 2023 Mar 22;26(4):106477. doi: 10.1016/j.isci.2023.106477. PMID: 37091234; PMCID: PMC10113792.
2022
Brandon AE, Small L, Nguyen TV, Suryana E, Gong H, Yassmin C, Hancock SE, Pulpitel T, Stonehouse S, Prescott L, Kebede MA, Yau B, Quek LE, Kowalski GM, Bruce CR, Turner N, Cooney GJ. Insulin sensitivity is preserved in mice made obese by feeding a high starch diet. Elife. 2022 Nov 17;11:e79250. doi: 10.7554/eLife.79250. PMID: 36394259; PMCID: PMC9711519.
Kebede MA, Piston DW. Sorting Out the Receptor Isoforms Underlying Dopamine Inhibition of Insulin Secretion. Diabetes. 2022 Sep 1;71(9):1831-1833. doi: 10.2337/dbi22-0018. PMID: 35984964.
2021
Yau B, Naghiloo S, Diaz-Vegas A, Carr AV, Van Gerwen J, Needham EJ, Jevon D, Chen SY, Hoehn KL, Brandon AE, Macia L, Cooney GJ, Shortreed MR, Smith LM, Keller MP, Thorn P, Larance M, James DE, Humphrey SJ, Kebede MA. Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic islet. iScience. 2021 Sep 9;24(10):103099. doi: 10.1016/j.isci.2021.103099. PMID: 34622154; PMCID: PMC8479695.
Yau and Kebede 2021 Islet Biology and Metabolism [Editorial, Special Issue] Metabolites 2021 Nov 18;11(11):786
Yau et al. 2021 Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic islet iScience 2021 Oct 22; 24, 103099
Germanos et al. 2021 Inside the Insulin Secretory Granule Metabolites 2021 Aug 5; 11(8):515.
Cottle et al. 2021 Machine Learning Algorithms, Applied to Intact Islets of Langerhans, Demonstrate Significantly Enhanced Insulin Staining at the Capillary Interface of Human Pancreatic β Cells. Metabolites 2021 Jun 7;11(6):363.
Wali et al. 2021 Impact of dietary carbohydrate type and protein-carbohydrate interaction on metabolic health. Nature Metabolism 2021 Jun;3(6):810-828.
Norris et al. 2021 Isolation and Proteomics of the Insulin Secretory Granule. Metabolites 2021 Apr 30;11(5):288.
Singh et al. 2021 Enhanced structure and function of human pluripotent stem cell-derived beta-cells cultured on extracellular matrix. Stem Cells Translational Medicine 2021 Mar;10(3):492-505.
Cottle et al. 2021 Structural and functional polarisation of human pancreatic beta cells in islets from organ donors with and without type 2 diabetes. Diabetologia 2021 Mar;64(3):618-629.
Burns et al. 2021 Pancreatic β-Cell-Specific Deletion of VPS41 Causes Diabetes Due to Defects in Insulin Secretion. Diabetes 2021 Feb;70(2):436-448.
2020
Yau et al. 2020 A Fluorescent Timer Reporter Enables Sorting of Insulin Secretory Granules by Age. Journal of Biological Chemistry 2020 Jul 3;295(27):8901-8911.
Ma et al. 2020 Arp2/3 nucleates F-actin coating of fusing insulin granules in pancreatic β cells to control insulin secretion. J Cell Sci. 2020 Feb 20. pii: jcs.236794
2019
Yau et al. 2019 Type 2 diabetes-associated single nucleotide polymorphism in Sorcs1 gene results in alternative processing of the Sorcs1 protein in INS1 β-cells. Scientific Reports volume 9, Article number: 19466 (2019)
Stöckli et al. 2019 ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation. Mol Metab. 2019 Jul;25:83-94.
Solon-Biet et al. 2019 Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control. Nature Metabolism, 1(5), 532-545.
Cartland et al. 2019 TRAIL-Expressing Monocyte/Macrophages Are Critical for Reducing Inflammation and Atherosclerosis. iScience. 2019 Feb 22;12:41-52.
Burchfield et al. 2018 High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice. J Biol Chem. 2018 Apr 13;293(15):5731-5745.
Kebede Lab 